Dietary supplement Myalgan has been developed at California University in Irvine in late 90-ties. This product was specially designed for people suffering from fibromyalgia. This purely natural formula provides ingredients that support body's own ability to effectively combat and soothe symptoms related to fibromyalgia. Some patients report that even dozen or so days of taking product could produce perceptible effect even though the illness latest for years.

Mylagan dietary supplement provides unique blend of four plant extracts: daisy leaf extract, grape leaf extract, pineapple fruit and stem extract, olive seed extract (seed fraction of olive's pit) and also essential amino acid l-tryptphan that like vitamins must be delivered in our food.

We have amended Myalgan composition in 2016. Two previous ingredients: sweet almond extract and orange juice powder replaced by tryptophan. More information about active ingredients of Myalgan are presented in section composition.

Tryptophan (pdf file) it is an essential amino acid that must be deliverd to the body with food like vitamins. Our ordinary diet provides relativelly little tryptophan and it is estimated that it accounts for as little as 1 % only of all amino acids provides with foods. Moreover tryptophan is basic "raw material" for our body for production of important hormones and neurotransmitters, which levels are low in fibromyalgia. Tryptophan requires active transport and competes for the same receptors with other neutral amino acids – tyrosine, phenylalanine, valine, leucine, and isoleucine. In fact, the best predictor of a given meal’s effect on brain tryptophan and serotonin levels is the serum ratio of tryptophan to the pool of large neutral amino acids. More clinically relevant, however, serotonin levels are enhanced by carbohydrate ingestion as insulin release accelerates the serum removal of competing valine, leucine, and isoleucine. Similarly, a higher percentage of protein in the diet slows serotonin elevation.

Myalgan can be taken by any person as a dietary supplement just to complete our everyday diet. However, it is recommended for people suffering from fibromyalgia particularly because it provides nutrients that may have beneficial effect on wellbeing. These ingredients have also positive effect on sleep and as a consequence give burst of energy and improve mood.

The aim of this study was to verify the information received from the people that took Myalgan about the effects that they have noticed. The test had a pilot study character. The evaluated preparation was a dietary supplement in tablets – Myalgan – the original formula providing (1) daisy leaf extract, (2) grape leaf extract, (3) olive seed extract, (4) pineapple fruit and stem extract, (5) sweet almond extract, (6) orange juice powder. The treatment and maintenance properties of the product were taken into consideration.

Investigated group and methods

The investigated group comprised of 25 women and 5 men in age from 32 to 61 years with diagnosed fibromyalgia syndrome. They were recruited to this study by internet. The investigated subjects took Myalgan in dose 1 tablet four times a day. The investigated subjects assessed various symptoms of fibromyalgia by filling up the self-evaluation questionnaire. The intensity of symptoms was assessed before and after 4 weeks of taking Myalgan in five level scale:
4 – very severe, pervasive, continuous, life disturbing symptoms,
3 – severe, considerable symptoms; present very often or continuously,
2 – moderate; present often or intermittent,
1 – slight or mild problems; generally mild or intermittent,
0 – none, not present at all,

Results

Results were presented in a graphical form. The results were grouped into following categories: (1) Stiffness and pain, (2) Sleep disorders and chronic fatigue, (3) Gastro-intestinal system symptoms, urogenital symptoms, emotional symptoms. There are more fibromyalgia related symptoms like from e.g. cardiovascular system, ENT, sensory organs, etc. However, they were present in few investigated subjects only and we did not take them into this report. Due to the small number of investigated subjects statistical analysis has not been performed.

proMylagan is a development of the Myalgan original formula. We have added a conditionally essential amino acid taurine to the original formula of: (1) daisy leaf extract, (2) grape leaf extract, (3) olive seed extract, (4) pineapple fruit and stem extract, (5) sweet almond extract, (6) orange juice powder in 2010.

Taurine – is an amino acid that does not take part in building up body proteins. Taurine is different from other amino acids because it contains sulphur in a sulphonic acid group in place of the carboxylic acid group as the other amino acids. Therefore taurine is not an amino acid in the true sense of this word. It is synthesized in human liver from cysteine and methionine. This special amino acid is essential for cardiovascular function, and development and function of skeletal muscle, the retina, and the central nervous system.

proMyalgan can be taken by any person as a dietary supplement just to complete the everyday diet. However, it is recommended particularly for people suffering from fibromyalgia because it provides nutrients that may have regulatory effect on muscle tension and as a consequence relaxing and soothing effect on periarticular (joint surrounding) tissue.

Results (continuation)

Concusions

1. Myalgan consumption revealed some positive effects for people with fibromyalgia syndrome.
2. Myalgan consumption was well tolerated and no adverse neither undesired effects were observed.
3. The product would deserve further investigation according to GCP standards and according up to date fibromyalgia criteria, and symptoms severity score in particular.

Situations where Myalgan or proMyalgan consumption might be recommended

Myalgan and proMyalgan are dietary supplements that could be taken be any person to complete the everyday diet. The beneficial effect of Myalgan and/or proMyalgan consumption has been confirmed by many testimonials received from random people that had taken these products. We list below some situations where supplementation of nutrients provided by Myalgan/proMyalgan might be beneficial.

• Fibromyalgia Syndrome – (FMS)
• Chronic Fatigue Syndrome – (CFS)
• Restless Legs Syndrome – (RLS)
• Neuromuscular Spastic Disorders – of different origin